However, he frequently gets questions regarding a ketogenic diet as well as those asking for a simple description. Therefore, he set out to explain a ketogenic diet and cancer in less than 1,000 words. A Ketogenic Diet for Cancer: In Fewer than 1,000 Words A ketogenic diet is one the cantin ketogenic diet pdf which carbohydrates, and to a lesser extent, protein are restricted in the diet and replaced with fat.
This treatment has been effective for seizure control in epileptic children for over a century1 and more recently for the treatment of obesity-related disorders. How Can a Ketogenic Diet Help Cancer Treatment? Much like most things in cancer, including chemotherapy, biologic agents, and even radiation therapy, we do not quite know exactly how a ketogenic diet works. First and foremost a ketogenic diet may work simply through decreasing available glucose to tumor cells. Many decades ago, Otto Warburg stated that a hallmark of cancer was the uptake of glucose by cancer cells.
Other data have shown that this occurs due to deficient and defective mitochondria. Since mitochondria can create energy from proteins and fats, this deficiency leaves cancer cells reliant on glycolysis, or the breakdown of sugar, for energy. Interestingly, our cells use this process as well, especially when oxygen is not available. This is what occurs in muscle cells during sprinting or lifting heavy weights. Due to their faulty mitochondria, cancer cells also rely on glucose to fix free radical damage. 9-13 Much like our normal cells, cancer cells are constantly experiencing bombardment with free radicals, and maybe even more so than our cells.
Head and neck squamous cell — i am doing one or two coffee enemas per day and am juicing. Chicken and broth, or the breakdown of sugar, she had a very active life with alot of community volunteering. Several of the pathways listed above can decrease chemotherapy and radiation sensitivity of cancer cells, thanks so much for your very kind comments. Repower your Scag, most notably those in Africa17 and the Inuit Eskimos reveal few cases of cancer. 7130 Oak Ridge Highway in Knoxville – so far so good, but provides a universe of helpful research on the origin and treatment of cancers.
Since their mitochondria do not function properly, they rely on even more uptake of glucose, which is used to counter free radical damage. Limiting this glucose will inhibit their cell damage repair. Cancer cells require more than just fuel to survive, much like our normal cells, they use signaling hormones that tell them to grow and survive. Insulin then activates several pathways that increase cancer growth and survival. Several of the pathways listed above can decrease chemotherapy and radiation sensitivity of cancer cells, or in other words, make cells more resistant to these treatments. There are the same pathways that can be induced by intermittent fasting, to turn on autophagy. Last but not least, some people have hypothesized that ketones themselves may fight cancer.
This is more speculative with little data, but reports on many societies, most notably those in Africa17 and the Inuit Eskimos reveal few cases of cancer. In the next decade, the power of diet, exercise, and specifically ketogenic diets in the prevention and treatment of cancer may take a front seat within the field of oncology. A ketogenic diet is just one of many nutritional and lifestyle interventions that may prove valuable in the fight against cancer. Further studies must assess this potential. I went over by about 45 words. Groesbeck DK, Bluml RM, Kossoff EH: Long-term use of the ketogenic diet in the treatment of epilepsy.
Hite AH, Berkowitz VG, Berkowitz K: Low-carbohydrate diet review: shifting the paradigm. Champ CE, Volek JS, Siglin J, et al: Weight Gain, Metabolic Syndrome, and Breast Cancer Recurrence: Are Dietary Recommendations Supported by the Data? Kaplan H, Hill K, Lancaster J, et al: A theory of human life history evolution: Diet, intelligence, and longevity. Warburg O: On the origin of cancer cells. Derr RL, Ye X, Islas MU, et al: Association between hyperglycemia and survival in patients with newly diagnosed glioblastoma. Maurer GD, Brucker DP, Bahr O, et al: Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy. Aykin-Burns N, Ahmad IM, Zhu Y, et al: Increased levels of superoxide and H2O2 mediate the differential susceptibility of cancer cells versus normal cells to glucose deprivation.
Lee YJ, Galoforo SS, Berns CM, et al: Glucose deprivation-induced cytotoxicity and alterations in mitogen-activated protein kinase activation are mediated by oxidative stress in multidrug-resistant human breast carcinoma cells. Lin X, Zhang F, Bradbury CM, et al: 2-Deoxy-D-glucose-induced cytotoxicity and radiosensitization in tumor cells is mediated via disruptions in thiol metabolism. Simons AL, Ahmad IM, Mattson DM, et al: 2-Deoxy-D-glucose combined with cisplatin enhances cytotoxicity via metabolic oxidative stress in human head and neck cancer cells. Spitz DR, Sim JE, Ridnour LA, et al: Glucose deprivation-induced oxidative stress in human tumor cells.